Nih.... Makan.

The basic etiology of androgen insensitivity syndrome is a loss-of-function mutation in the androgen receptor (AR) gene. This AR gene has been localized to the long arm of the X chromosome (ie, Xq11-13). Over 200 such mutations have been described, including complete and partial gene deletions, point mutations, and small insertions/deletions. These mutations can cause a variety of functional defects, ranging from a complete loss of receptors on the cell surface because of incomplete protein synthesis to alterations in substrate binding affinity. Altered substrate binding affinity causes a signal transmission loss, despite normal cell surface receptor numbers. While the genotypes causing complete androgen insensitivity syndrome are consistent in phenotypic presentation, the genotype/phenotype relationships for the mutations causing partial androgen insensitivity syndrome remain unclear.

Loss of AR function means that, despite normal levels of androgen synthesis, the typical postreceptor events that mediate the effects of hormones on tissues do not occur. This results in the phenotype of prenatal undervirilization of external genitalia, absence of pubic and axillary hair, lack of acne, and absence of voice changes at puberty.

Sumber:
http://emedicine.medscape.com/article/924996-overview

Ntah... Tergantng interpretasi sendiri..

Uummm.... Virilization itu sebenarnya adalah proses pembentukan tanda2 seks.
 

virilization refers to the biological development of sex differences, changes which make a male body different from a female body

Jadi virilization itu ada yang fisiologis ada yang patologis..

http://en.wikipedia.org/wiki/Virilization

Malas baca medscape (kalo gak terpaksa), wiki lebih mudah...

NAh, biar OOT, kita bahas medscape dan wiki yuk.. Udah lama gak OOT..

apa kegunaannya.? XDDD

bisa diobatin ga.?

berapa persen orang di dunia ini yg bisa kena itu...?

ok,, mari diskusikan.. XDD