memang pemanis sintesis (aspartame) itu sangat berbahaya ya? soalnya saya cari di 1 refresi dengan refrensi lainnya berbeda.

ini di handbook of pharmaceutical excipients:

aspartame is widely used in oral pharm formulations, beverages, and food products as an intense sweetener, and is generally regarded as a nontoxic material. however, the use of aspartame has been of some concern owing to the formation of the potentially toxic metabolites methanol, aspartic acid, and phenylalanine, of these materials, only phenylalanine is produced in sufficient quantities, at normal aspartame intake levels, to cause concern. in the normal healthy individual any phenylalanine produced is harmless; however, it is recommended that aspartame be avoided or its intake restricted by those persons with phenylketonuria.
the WHO has set an acceptable daily intake (ADI) for aspartame at up to 40 mg/kg body-weight. additionally, the ADI of diketopiperazine (an impurity found in aspartame) has been set by the WHO at up to 7.5 mg/kg body-weight.
a number of adverse effects have been reported following the consumption of aspartame, particularly in individuals who drink large quantities (up to 8 L per day in one case) of aspartame-sweetened beverages. reported adv effects incl: headaches; grand mal seizure; memory loss; gastrointestinal symptoms; and dermatological symptoms. however, scientifically controlled peer-reviewed studies have consistently failed to produce evidence of a causal effect between aspartame consumption and adverse health events. controlled and thorough studies have confirmed aspartame's safety and found no credible link between consumption of aspartame at levels found in the human diet and condition related to the nervous system and behavior, nor any other symptom or illness. aspartame is well documented to be nongenotoxic and there is no credible evidence that aspartame is carcinogenic.
although aspartame has been reported to cause hyperactivity and behavioral problems in children, a double-blind controlled trial of 48 preschool-age children fed diets containing a daily intake of 38 +/- 13 mg/kg body-weight of aspartame for 3 weeks showed no adv effects attributable to aspartame, or dietary sucrose, on children's behavior or cognitive function.